GPT‑5.4 and Maria enhanced Chan–Lam coupling for sulfonamides

Friends, sharing an OpenAI development: GPT‑5.4 coupled with Maria (Molecule.one) proposed TEMPO as an additive and improved Chan–Lam coupling for primary sulfonamides.

Key facts:
- Maria screened 10,080 reactions; TEMPO increased yields: improvements in 88% of boronic acids and 83% of sulfonamides; average yield rose from 16.6% to 25.2%.
- Manual validation: 11 of 14 pairs showed increases, often over twofold.
- Near‑autonomous format: humans selected plans and adjusted experiments.

Why it matters: makes Chan–Lam more practical for med‑chem.

How quickly do you think AI + automated labs will become routine in synthesis?

#OpenAI #medchem #automation #AI